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Thyroid carcinoma, sporadic medullary

MedGen UID:
371684
•Concept ID:
C1833929
•
Neoplastic Process
Synonym: THYROID CARCINOMA, SPORADIC MEDULLARY
 
OMIM®: 164761

Professional guidelines

PubMed

Evaluation of grade in a genotyped cohort of sporadic medullary thyroid carcinomas.
Najdawi F, Ahmadi S, Capelletti M, Dong F, Chau NG, Barletta JA
Histopathology 2021 Sep;79(3):427-436. Epub 2021 Jun 15 doi: 10.1111/his.14370. PMID: 33763905
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Thyroid 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335. PMID: 25810047Free PMC Article
Evidence-based approach to the management of sporadic medullary thyroid carcinoma.
Moley JF, Fialkowski EA
World J Surg 2007 May;31(5):946-56. doi: 10.1007/s00268-006-0846-2. PMID: 17426901

Recent clinical studies

Etiology

FAMILIAL NON-MEDULLARY THYROID CARCINOMA.
Guda BB, Komisarenko II, Ostafiichuk MV, Tronko MD
Exp Oncol 2023 Jun 26;45(1):70-78. doi: 10.15407/exp-oncology.2023.01.070. PMID: 37417280
Chromosomal alterations in sporadic medullary thyroid carcinoma and correlation with outcome.
Ramone T, Romei C, Ciampi R, Casalini R, Valetto A, Bertini V, Raimondi F, Onoja A, Prete A, Matrone A, Gambale C, Piaggi P, Torregrossa L, Ugolini C, Elisei R
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Aug 2 doi: 10.1530/ERC-22-0251. PMID: 37343157
Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Medullary thyroid carcinoma.
Griebeler ML, Gharib H, Thompson GB
Endocr Pract 2013 Jul-Aug;19(4):703-11. doi: 10.4158/EP12430.RA. PMID: 23512389
Medullary thyroid carcinoma.
Pacini F, Castagna MG, Cipri C, Schlumberger M
Clin Oncol (R Coll Radiol) 2010 Aug;22(6):475-85. doi: 10.1016/j.clon.2010.05.002. PMID: 20627492

Diagnosis

Medullary thyroid cancer - An update.
Fugazzola L
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101655. Epub 2022 Mar 31 doi: 10.1016/j.beem.2022.101655. PMID: 35422397
Management of medullary carcinoma of the thyroid: a review.
Jayasinghe R, Basnayake O, Jayarajah U, Seneviratne S
J Int Med Res 2022 Jul;50(7):3000605221110698. doi: 10.1177/03000605221110698. PMID: 35822284Free PMC Article
Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines.
Thomas CM, Asa SL, Ezzat S, Sawka AM, Goldstein D
Curr Oncol 2019 Oct;26(5):338-344. Epub 2019 Oct 1 doi: 10.3747/co.26.5539. PMID: 31708652Free PMC Article
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Thyroid 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335. PMID: 25810047Free PMC Article

Therapy

Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
The importance of the RET gene in thyroid cancer and therapeutic implications.
Salvatore D, Santoro M, Schlumberger M
Nat Rev Endocrinol 2021 May;17(5):296-306. Epub 2021 Feb 18 doi: 10.1038/s41574-021-00470-9. PMID: 33603219
Management of Medullary Thyroid Cancer.
Viola D, Elisei R
Endocrinol Metab Clin North Am 2019 Mar;48(1):285-301. Epub 2018 Dec 26 doi: 10.1016/j.ecl.2018.11.006. PMID: 30717909
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Thyroid 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335. PMID: 25810047Free PMC Article
Cabozantinib in progressive medullary thyroid cancer.
Elisei R, Schlumberger MJ, Müller SP, Schöffski P, Brose MS, Shah MH, Licitra L, Jarzab B, Medvedev V, Kreissl MC, Niederle B, Cohen EE, Wirth LJ, Ali H, Hessel C, Yaron Y, Ball D, Nelkin B, Sherman SI
J Clin Oncol 2013 Oct 10;31(29):3639-46. Epub 2013 Sep 3 doi: 10.1200/JCO.2012.48.4659. PMID: 24002501Free PMC Article

Prognosis

FAMILIAL NON-MEDULLARY THYROID CARCINOMA.
Guda BB, Komisarenko II, Ostafiichuk MV, Tronko MD
Exp Oncol 2023 Jun 26;45(1):70-78. doi: 10.15407/exp-oncology.2023.01.070. PMID: 37417280
Medullary Thyroid Cancer: Updates and Challenges.
Gild ML, Clifton-Bligh RJ, Wirth LJ, Robinson BG
Endocr Rev 2023 Sep 15;44(5):934-946. doi: 10.1210/endrev/bnad013. PMID: 37204852Free PMC Article
Diagnostic Challenges of Medullary Thyroid Carcinoma.
Leimbach RD, Hoang TD, Shakir MKM
Oncology 2021;99(7):422-432. Epub 2021 Apr 20 doi: 10.1159/000515373. PMID: 33878761
Management of Medullary Thyroid Cancer.
Viola D, Elisei R
Endocrinol Metab Clin North Am 2019 Mar;48(1):285-301. Epub 2018 Dec 26 doi: 10.1016/j.ecl.2018.11.006. PMID: 30717909
Medullary thyroid carcinoma.
Griebeler ML, Gharib H, Thompson GB
Endocr Pract 2013 Jul-Aug;19(4):703-11. doi: 10.4158/EP12430.RA. PMID: 23512389

Clinical prediction guides

Chromosomal alterations in sporadic medullary thyroid carcinoma and correlation with outcome.
Ramone T, Romei C, Ciampi R, Casalini R, Valetto A, Bertini V, Raimondi F, Onoja A, Prete A, Matrone A, Gambale C, Piaggi P, Torregrossa L, Ugolini C, Elisei R
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Aug 2 doi: 10.1530/ERC-22-0251. PMID: 37343157
Medullary Thyroid Cancer: Updates and Challenges.
Gild ML, Clifton-Bligh RJ, Wirth LJ, Robinson BG
Endocr Rev 2023 Sep 15;44(5):934-946. doi: 10.1210/endrev/bnad013. PMID: 37204852Free PMC Article
Diagnostic Challenges of Medullary Thyroid Carcinoma.
Leimbach RD, Hoang TD, Shakir MKM
Oncology 2021;99(7):422-432. Epub 2021 Apr 20 doi: 10.1159/000515373. PMID: 33878761
The importance of the RET gene in thyroid cancer and therapeutic implications.
Salvatore D, Santoro M, Schlumberger M
Nat Rev Endocrinol 2021 May;17(5):296-306. Epub 2021 Feb 18 doi: 10.1038/s41574-021-00470-9. PMID: 33603219
Cabozantinib in progressive medullary thyroid cancer.
Elisei R, Schlumberger MJ, Müller SP, Schöffski P, Brose MS, Shah MH, Licitra L, Jarzab B, Medvedev V, Kreissl MC, Niederle B, Cohen EE, Wirth LJ, Ali H, Hessel C, Yaron Y, Ball D, Nelkin B, Sherman SI
J Clin Oncol 2013 Oct 10;31(29):3639-46. Epub 2013 Sep 3 doi: 10.1200/JCO.2012.48.4659. PMID: 24002501Free PMC Article

Recent systematic reviews

Initial surgical management of sporadic medullary thyroid cancer: Guidelines based optimal care - A systematic review.
Cohen O, Tzelnick S, Randolph G, Rinaldo A, Álvarez F, Rodrigo JP, Saba NF, Nuyts S, Corry J, Mäkitie AA, Vander Poorten V, Nathan CA, Piazza C, Ferlito A
Clin Endocrinol (Oxf) 2024 May;100(5):468-476. Epub 2024 Mar 12 doi: 10.1111/cen.15041. PMID: 38472743
Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Clinical significance of RET and RAS mutations in sporadic medullary thyroid carcinoma: a meta-analysis.
Vuong HG, Odate T, Ngo HTT, Pham TQ, Tran TTK, Mochizuki K, Nakazawa T, Katoh R, Kondo T
Endocr Relat Cancer 2018 Jun;25(6):633-641. Epub 2018 Apr 3 doi: 10.1530/ERC-18-0056. PMID: 29615431
Expression of protein kinase A regulatory subunits in benign and malignant human thyroid tissues: A systematic review.
Del Gobbo A, Peverelli E, Treppiedi D, Lania A, Mantovani G, Ferrero S
Exp Cell Res 2016 Aug 1;346(1):85-90. Epub 2016 Jun 16 doi: 10.1016/j.yexcr.2016.06.004. PMID: 27321957
Epigenetics in Medullary Thyroid Cancer: From Pathogenesis to Targeted Therapy.
Vitale G, Dicitore A, Messina E, Sciammarella C, Faggiano A, Colao A
Recent Pat Anticancer Drug Discov 2016;11(3):275-82. doi: 10.2174/1574892811666160614115356. PMID: 27306881

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